Overexpression of C/EBPα upregulates p53 gene expression through PPAR γ and then upregulates Fas, tumor necrosis-related factor apoptosis-inducing ligand and DR5 expression, thereby inducing the apoptosis of HSCs and inhibiting liver fibrosis (Wang et al., 2009). The gene discussed is CEBPA; the disease is Hepatic fibrosis.