Notably, activation of the PI3K/AKT signaling pathway in hepatoma cells blocks C/EBPα-mediated inhibition of mitosis and proliferation, revealing that hepatoma cells might escape C/EBP α-mediated inhibition of tumor cell proliferation via activation of the PI3K/AKT pathway (Datta et al., 2007). Here, CEBPA is linked to hepatocellular carcinoma.