FGFR1 and neoplasm: FGFR1 has been reported to have both oncogenic and tumor suppressive potential (Katoh and Nakagama, 2014) and the tyrosine kinase RET has long been established as a classic proto-oncogene but was found to act as a TSG in colorectal carcinomas (Eng, 1999; Luo et al., 2013).