TP53 and cancer: SUV39H2 maintains standard biological function, the loss of which promotes carcinogenesis, and its upregulation as an oncogene often leads to cancer initiation and progression (Li et al., 2019) WDR75 knockdown triggered the RPL5/RPL11-dependent stabilization checkpoint for p53, resulting in decreased cell proliferation and senescence (Moudry et al., 2022).