PIK3CA and neoplasm: Numerous gene mutations were discovered to be useful prognostic indicators for tumorigenesis; for example, genetic mutations in BRAF, PIK3CA, TP53, KRAS, and NRAS were discovered to be correlated with extramural venous invasion in baseline MRI, as well as poor clinical tumor regression and a trend towards much worse progression-free survival at 5 years (Sclafani et al., 2020).