Its mechanism of action is by inhibiting urokinase and tyrosine kinase, which activates VEGF, epidermal growth factor (EGF), and fibroblast growth factor (FGF).13 In 2005, a previous study in Japan stated that EGCG induces bothin vitro andin vivo liver cell apoptosis to improve the prognosis of HCC.In vitro studies showed that the effective level of EGCG varies from 1 to 100 mol/L. This evidence concerns the gene VEGFA and hepatocellular carcinoma.