In fact, the presence of NKG2D-ligands (NKG2D-L) in patient sera, together with the decrease of NKG2D receptor on effector lymphocytes, has been associated to worse prognosis of patients suffering many different types of cancer, both solid and haematological tumours [(Campos-Silva et al., 2022b) and references therein]. Here, KLRK1 is linked to cancer.