Since the two proteins PHIP and CUL4B belong to the same complex and are involved in the same processes (DNA repair, fork stability and genome integrity), as mentioned before, we chose individuals with CUL4B associated Cabezas syndrome to investigate whether their facial gestalt overlaps with that of CHUJANS or can be clearly distinguished by next-generation phenotyping approaches like GestaltMatcher (reported in 4.4). This evidence concerns the gene CUL4B and X-linked intellectual disability, Cabezas type.