DEPTOR and osteoporosis: Increased ALP activity in DEPTOR knock down in BMSC has been previously described (Chen et al., 2018), this study suggested that DEPTOR acts as a negative regulator of osteogenesis and linked high DEPTOR levels to the progress of osteoporosis, where fat accumulation has been documented (Devlin and Rosen, 2015; Veldhuis-Vlug and Rosen, 2017).