In the relation of risk score with oncogenic pathways, EGFR, hypoxia, PI3K, and VEGF pathways were positively correlated with risk score (R = 0.42, 0.42, 0.36, and 0.28, respectively) (Figure 8E), suggesting that these pathways may be highly involved in the TME modulation and tumor progression. The gene discussed is VEGFA; the disease is neoplasm.