Therefore, to define whether aberrant expression of transcription factors in CD4 T cell associate with the development of IRIS, we investigated the role of Eomes and Tbet in an experimentally induced MAC-IRIS mouse model and compared the phenotype of Mtb-specific IFNγ+CD4+ T cells between HIV-associated TB patients who developed TB-IRIS and those who did not. The gene discussed is CD4; the disease is tuberculosis.