Likewise, Tbet expression in Mtb-specific IFNγ+CD4+ T cells was comparable between TB-IRIS and non-IRIS groups; approximately 60% of cells expressed intermediate levels of Tbet (Tbet dim, Tbet+) and 25% expressed high Tbet levels at baseline (Tbet high, Tbet++) (Supplementary Figure 4C and D). This evidence concerns the gene TBX21 and tuberculosis.