Although HLA-DR expression was comparable across the different Eomes and Tbet subsets in both groups, HLA-DR expression was higher in TB-IRIS compared to non-IRIS patients in specific Eomes/Tbet subsets, including Eomes + Tbet + (median: 83.9% vs 57.9%, respectively; P = .032) and Eomes- Tbet++ (median: 83.3% vs 36.4%, respectively; P = .032) (Figure 5A). Here, EOMES is linked to tuberculosis.