However, the fold change in Mtb-specific IFNγ+CD4+ T-cell frequency between BL and week 2 was significantly higher in the TB-IRIS group compared to the non-IRIS group (median fold change = 1.9 [interquartile range {IQR}, 0.83–19.3] and 0.9 [IQR, 0.25–1.6], respectively; P = .04) (Figure 2C). This evidence concerns the gene CD4 and tuberculosis.