Of the nine turning point articles, six discussed the role of neural network hubs and the HPA axis in PTSD research (Milad et al., 2009; Brewin et al., 2010; Shin and Liberzon, 2010; Pitman et al., 2012; van Zuiden et al., 2012; Daskalakis et al., 2013) and one article explored the role of the pituitary adenylyl cyclase activating polypeptide PAC1 receptor pathway in human stress responses (Ressler et al., 2011). The gene discussed is ADCYAP1R1; the disease is post-traumatic stress disorder.