Moreover, CXCR3+% and PD-L1+CXCR3+% associated positively with both splenomegaly (r = 0.348, P = 0.002; r = 0.268, P = 0.018) and general lymphadenopathy (r = 0.362, P = 0.001; r = 0.304, P = 0.007). This evidence concerns the gene CD274 and Splenomegaly.