Finally, six genes were identified as central risk genes for DKD with IBD, including matrix metalloproteinase 2 (MMP2), hepatocyte growth factor (HGF), fibroblast growth factor 2 (FGF2), interleukin (IL)-18, IL-13, and C–C motif chemokine ligand 5 (CCL5), and their detailed information in the PPI network is displayed in Table 1. This evidence concerns the gene IL18 and diabetic kidney disease.