The results showed that five lncRNAs including HOTAIR, DANCR, PVT1, LINC00511, and NEAT1 and 16 miRNAs and five of their targets—VEGFA, BTG2, E2F3, IRAK1, and SMAD4—have significantly different expression patterns in normal individuals compared to those with breast cancer (Figure 5; Supplementary Figures S14, S15; Supplementary Table S15). This evidence concerns the gene SMAD4 and breast cancer.