TARDBP and amyotrophic lateral sclerosis: We found that the genetic ablation of Hoip or the treatment with the HOIPIN-8 reduced the aggregates of the ALS-associated A315T mutant of truncated TDP-43 in Neuro2a cells (Figure 5D), and the quantitative analysis revealed that the intensities and sizes of the aggregates were significantly reduced by HOIPIN-8 (Figure 5E) (Zhang et al., 2022).