VHL and Alzheimer disease: For the treatment of tauopathy in AD and FTD, peptide-based PROTACs for tau such as TH006, which contains a tau recognition sequence (YQQYQDATADEQG), short linker, VHL recruit motif, and cell-penetrating poly-Arg region, were initially constructed and decreased the tau levels in the cells and the brains of an AD mouse model (Chu et al., 2016).