MAPT and tauopathy: Importantly, Silva et al. developed hetero-bifunctional molecules, such as QC-01–175, which links the PET probe-derived tau ligand of T807 and the CRBN ligand, pomalidomide, that ameliorate tauopathy in FTD-patient derived neuronal cells (Figure 5A) (Silva et al., 2019; Silva et al., 2022).