Finerenone is a potent and selective nsMRA that blocks MR overactivation andinhibits expression of proinflammatory and profibrotic mediators, includingthose associated with CKD progression.75, , , -79 Recently 2 pivotal trialsexamining cardiorenal endpoints and safety of finerenone in addition to RAASinhibitors in people with DKD were published. The gene discussed is NR3C2; the disease is chronic kidney disease.