While hypoglycemia is uncommon with SGLT2 inhibitors alone,their use in combination with drugs that are associated with increasedhypoglycemia risk (eg, sulfonylurea or insulin) may result in an increased riskof hypoglycemia.32 SGLT2 inhibitors are also not significantly associatedwith an increased risk of acute kidney injury (AKI), confirming their safety inpatients with CKD with and without diabetes.6,7,48. This evidence concerns the gene INS and acute kidney injury.