For instance, CIITA continues to be important by providing resistance factors to modern infectious diseases such as Ebola virus and SARS-CoV-2 (Bruchez et al. 2020), and IL18R1 has been shown to confer protection against more severe clinical dengue phenotypes through IL1α downregulation (Yeo et al. 2014). This evidence concerns the gene IL18R1 and dengue disease.