When selected cells were exposed to glucose deprivation-induced metabolic stress (e.g., glucose deprivation), it led to more significant induction of cancer stemness-related genes (e.g., WNT, ALDH1A1, EGFR, and CD44), PGC1α, ATP2B isoforms, HNF4α, and NFκB than those in parental cells (Fig. 1D, E) compared with glucose present conditions. This evidence concerns the gene ALDH1A1 and cancer.