When selected cells were exposed to glucose deprivation-induced metabolic stress (e.g., glucose deprivation), it led to more significant induction of cancer stemness-related genes (e.g., WNT, ALDH1A1, EGFR, and CD44), PGC1α, ATP2B isoforms, HNF4α, and NFκB than those in parental cells (Fig. 1D, E) compared with glucose present conditions. The gene discussed is HNF4A; the disease is cancer.