When APO-B/APO-A1 is at a low level (APO-B/APO-A1 < 0.46), LDL and HDL metabolism are relatively normal, so the risk of LGA is lower than that of 0.46–0.65; when APO-B/APO-A1 is > 0.65, indicative of abnormal levels of LDL and HDL, hypertriglyceridemia will cause damage vascular endothelial cells regardless of high LDL or low HDL. The gene discussed is APOA1; the disease is hypertriglyceridemia.