LIG1 and cancer: This study suggests that Lactobacillus crispatus can significantly inhibit the proliferation, induce apoptosis and inhibit cell migration of Ect1/E6E7 cells in a time-dependent manner, significantly promote the secretion of Th1 cytokines and inhibit the secretion of Th2 cytokines by Ect1/E6E7 cells, and significantly inhibit the potential cancer promoting genes ABCG2, LIG1, PCNA, ATM, OGG1 and HMGB1 protein expression, but promote the tumor suppressor gene TDG protein expression.