CCNA2 and cervical carcinoma: Wang et al. [25] used Lactobacillus supernatants (LS) from Lactobacillus curlicus, Lactobacillus gargari and Lactobacillus Jennings to treat cervical cancer CaSki cells, and found that LS could inhibit the proliferation of CaSki cells, induce cell arrest in S phase, down regulate the expression of HPV E6 and E7 oncogenes, CDK2 and Cyclina, and up regulate the expression of P21, so as to play an anti-tumor role.