CD47 and acute myeloid leukemia: In oncology study, CD47 was initially discovered as a tumor antigen in human ovarian cancer, and later was found overexpressed in various lymphomas and hematological tumors, such as non-Hodgkin's lymphomas (NHL) [2], T-cell lymphoma [3], acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) [4].