Moreover, the expression of HSP90 in the exosomes from rat plasma was significantly increased after RIPC, suggesting that HSP90 in RIPC-Exo potentially played a central role in cardioprotection by reducing cardiomyocyte apoptosis and myocardial infarction through inhibition of complement activation, local and systemic inflammation, and JNK signalling. The gene discussed is MAPK8; the disease is myocardial infarction.