INS and type 1 diabetes mellitus: Breen et al. also reported that DJB rapidly improves hyperglycemia in rats with streptozotocin-induced T1DM, which are insulin deficient, and Sprague Dawley rats on 2POD, and revealed that these effects were achieved not through changes in insulin concentration, body mass, or food intake, but by a reduction in endogenous glucose concentration, caused by diverting nutrient flow directly into the jejunum32.