A remarkable resistance to these malaria parasites is found in the majority of the Sub-Saharan African population due to a silencing mutation in the promoter region of ACKR1, located on chromosome 1q23.2, abolishing ACKR1 expression on erythrocytes but retaining expression on endothelial cells (Duffy-negative phenotype) [40, 41]. The gene discussed is ACKR1; the disease is malaria.