Acute lung injury is characterized by direct acute injury to the lungs associated with pulmonary edema and impaired gas exchange, caused by infection, trauma, noxious compounds, systemic inflammation, etc. In acute lung injury, elevated CXCL8 and immune complexes of anti-CXCL8 autoantibodies enhanced neutrophil accumulation and survival, leading to neutrophil-associated damage [123]. This evidence concerns the gene CXCL8 and infection.