Endothelial cells also showed strong interactions with cancer cells (Fig. 2c); in particular, perivascular cancer cells exhibited reduced Ki67:CC3 ratios compared with those that avoided blood vessels (Fig. 2d and Extended Data Fig. 6a), suggesting that direct contact with the vasculature may impede cancer cell expansion30—a finding that may provide insight into LTS tumour biology. Here, MKI67 is linked to cancer.