CD163 and neoplasm: Finally, endothelial cells tended to interact with many immune populations in high-grade tumours compared with low-grade tumours, including CD163+ macrophages and monocytes (Fig. 2d, box 5); these interactions may be reminiscent of innate regulation of vascular inflammation, consistent with our observation that immune infiltration was highest in the solid pattern (Fig. 1g), driven largely by differences within the myeloid compartment (Fig. 1h).