Additionally, non-small cell lung cancer (NSCLC) may have driver mutations, including EGFR, ALK, ROS1, RET and BRAF10,11 . Furthermore, next-generation sequencing (NGS), such as the OncomineTM Dx Target Test® (ODxTT), to measure multiple gene mutations simultaneously have been used as a companion diagnostic test, but the test failure rate of ODxTT was reported to be up to 28%12. The gene discussed is RET; the disease is non-small cell lung carcinoma.