CALCR and neoplasm: In MDA-MB-231 depleted of METTL3, GO analysis of up-regulated genes revealed generic functions (Supplementary Fig. 2P), which included the tumor suppressors RARRES2, ITLN1, CALCR and UTRN. On the other hand, GO analysis of down-regulated genes showed that cellular response to lipopolysaccharide, angiogenesis, negative regulation of cell proliferation, and cell adhesion were among the most enriched biological processes (Supplementary Fig. 2Q).