We observed that the AS events for COMMD4_AS2, GNAS, MATR3,COMMD4_AS1 and RHOC displayed a significant higher PSI value in cancer patients than in normal samples (Fig. 6A–E), while the PSI values were significantly lower for MARK3, POLDIP3 and FASTK in patients with breast cancer (Fig. 6F–H). The gene discussed is MARK3; the disease is cancer.