In MDA-MB-231 depleted of METTL3, GO analysis of up-regulated genes revealed generic functions (Supplementary Fig. 2P), which included the tumor suppressors RARRES2, ITLN1, CALCR and UTRN. On the other hand, GO analysis of down-regulated genes showed that cellular response to lipopolysaccharide, angiogenesis, negative regulation of cell proliferation, and cell adhesion were among the most enriched biological processes (Supplementary Fig. 2Q). This evidence concerns the gene METTL3 and neoplasm.