Furthermore, a two-sample MR approach leveraging large GWAS and eQTL databases suggested a potential causal role for IL4, IL1RL1, RP11-13A1.1, FCER1A and MS4A2, RUNX1, and ACLS6 expression in various allergic diseases and serum IgE levels. The gene discussed is FCER1A; the disease is allergic disease.