It is found that high concentration of serum PGD2 was statistically correlated with low International Prognostic Index (IPI) score, GCB subtype, B symptoms absence and low lymphocyte-to-monocyte ratio (LMR), indicating the association between PGD2 and DLBCL progression (Fig. 1B, Supplementary Table 2). Here, PTGDS is linked to diffuse large B-cell lymphoma.