GNRH1 and Dravet syndrome: Notably, overexpressing a transcriptional regulator of the GnRH developmental switch (called miR-200b) in the hypothalamus of Ts65Dn mice increased the number of GnRH-expressing neurons, rectified the changes in hippocampal gene expression and neuronal activity, and rescued the olfactory and cognitive phenotypes.1 miR-200b can activate multiple transcriptional targets, meaning other effector pathways could underlie these changes in hippocampal gene expression and DS phenotypes.