GNRH1 and Dravet syndrome: To confirm their hypothesis, the authors characterized the progression of olfactory and cognitive symptoms in a DS mouse model (Ts65Dn mice) and assessed whether they were temporally correlated with any shifts in GnRH signaling.1 Similar to the human DS phenotype, olfactory deficits in Ts65Dn mice first arose during the prepubertal period and were followed by impaired memory early in adulthood (Fig. 1a).