TP53 and cancer: As is known to all, cancer-promoting gain-of-function activities can be induced by mutant p53 (mtp53) proteins.21 Research reports, that the cytoplasmic DNA sensing machinery, cGAS-STING-TBK1-IRF3, which stimulates the innate immune response, is disrupted by mtp53.21 But whether there is a link to GPR162 has not been reported.