In previous studies, we found that Lymphoid-specific helicase (LSH) plays a crucial part in the progression of cancer, which has major implications for the development of novel strategies to treat cancer.10–16 We have confirmed that LSH can mediate p53 to regulate ferroptosis and apoptosis of tumor cells.17,18 In our research, we found that LSH is a key molecule that regulates p53-related lncRNA (P53RRA).19,20 In addition, GPR162 is abnormally lowly expressed in lung cancer cell lines overexpressing P53RRA, but its relationship with LSH is not yet known. The gene discussed is HELLS; the disease is lung cancer.