More significantly, we discovered novel diagnostics biomarkers (CLDN3 for ADC and KRT14 for SCC) with validation of clinical tissues and innovatively established prognostic biomarkers based on several unique cell clusters (malignant epithelial cells, tip cells, and SPP1/C1QC macrophages) embodying cancer hallmarks using TCGA data. The gene discussed is KRT14; the disease is cancer.