SPP1 and cancer: Given that sprouting angiogenesis, ECM remodeling and immune escape are significant hallmarks of cancer, we elucidated the marked cell–cell interactions of the following four representative cell types in HPV‐positive SCC, HPVA ADC and NHPVA ADC: tip cells (Figure7A), myCAFs (Figure 7B), SPP1+ macrophages (Figure 7C), and CD8+ Tex cells (Figure 7D).