To better understand these events and their integration for pathway outputs in the context of ccRCC, we have used chromatin immunoprecipitation coupled to next-generation DNA sequencing (ChIP-seq) to examine pan-genomic patterns of HIF-1α, HIF-2α, AHR, and HIF-1β/ARNT binding under co-activating stimuli and have linked these findings to gene expression changes analysed by RNA-sequencing. Here, ARNT is linked to nonpapillary renal cell carcinoma.