DHPS and neurodevelopmental disorder: Remarkably, we could further show that this defect in phagocytosis also occurred when we replaced the endogenous version of DHPS in THP-1 cells with recessive rare variants of mutated DHPS found in patients (N173S and ΔY305-I306) with neurodevelopmental disorders or with a DHPS variant mutated in the predicted binding site of spermidine (D243A).