By analysis of the complete datasets of three single-cell collections, we observed that C1QA, C1QB, and C1QC (but not APOE) were expressed almost exclusively in macrophages (Supplementary Figure S7), as described.64, 65, 66 Macrophages from tumour and peritumoural tissues in CRC and lung cancer demonstrated comparable levels of expression of C1QA-C and APOE (Supplementary Figures S8 and S9). This evidence concerns the gene APOE and lung cancer.