In PCa patient datasets, the highest levels of PIP4K2A correlated with lower AR signaling in both TCGA (PRAD, P = 4.9 × 10−16, N = 498) and SU2C datasets (SU2C, P = 5.1 × 10−6, N = 209) (Fig. 1, B and C). Here, AR is linked to posterior cortical atrophy.