While the transcript abundance of PIP4K2B and PIP4K2C did not vary between cell lines, PIP4K2A, the most catalytically active isoform (29, 30), shows a marked range of expression between cell lines with NCI-H660 (neuroendocrine PCa model) and VCaP (AR responsive) being the highest and lowest, respectively. Here, AR is linked to posterior cortical atrophy.