TFEB transcription activation is a biomarker of loss of mTORC1 anabolic activity, and we observed an up-regulation of three of four tested TFEB target genes (CTSD, NEU1, HEXA, and CTSF) following siPIP4K2A depletion in LNCaP cells in AD (Fig. 4E). The gene discussed is CTSD; the disease is Alzheimer disease.