PIP4K2A, PIP4K2B, and PIP4K2C transcript expression was detected in clinically localized [The Cancer Genome Atlas (TCGA)-Prostate Adenocarcinoma (PRAD), N = 498] and advanced, metastatic PCa [Stand Up 2 Cancer-Prostate Cancer Foundation (PCF) (SU2C, N = 209)] datasets. This evidence concerns the gene PIP4K2B and Familial prostate cancer.