GSK3B and diabetes mellitus: Therefore, we surmise that the activation of GSK3β found in these patients constitutes an additional link in the pathogenic chain that leads from increased [Ca2+]cyto to alteration in muscle utilization of glucose, then to hyperglycemia and diabetes (Tammineni et al., 2020; Altamirano et al., 2019; DeFronzo and Tripathy, 2009).