DMD and Heat Stroke: The question is relevant beyond the MHS syndrome, as a similar dysregulation of Ca2+ homeostasis is found in other conditions, including related inheritable diseases with mutations in couplon proteins (Ríos et al., 2015; Dowling et al., 2014; Lawal et al., 2020), DMD (Edwards et al., 2010; Boittin et al., 2006; Bellinger et al., 2009), Exertional and Non-Exertional Heat Stroke (Leon and Bouchama, 2015; Hopkins et al., 1991) and Statin-related Myotoxicity (Turner and Pirmohamed, 2019).