Taken together, the present observations and those in Tammineni et al., 2020 identify a multi-lane pathway, where Ca2+ activation, proteolysis and phosphorylation, involving at a minimum calpain 1, GSK3β, GS, GP, PhK, and GLUT4, lead from the primary Ca2+ dysregulation to hyperthermia and diabetes (Figure 9). The gene discussed is SLC2A4; the disease is diabetes mellitus.