Hepatic and skeletal muscle silencing of the four genes named above improved the insulin resistance by inducing phosphorylation of Akt (Gómez-Valadés et al., 2008; Kern et al., 2014; Chen et al., 2015; Lian et al., 2012; Hesselbarth et al., 2017). Here, AKT1 is linked to Insulin resistance.