Independent of PPAR-α, fenofibrate inhibits the downregulation of C-X-C motif chemokine receptor 2 (CXCR2) by blocking extracellular-signal-regulated kinase (ERK) phosphorylation and subsequent expression of G protein-coupled receptor kinases 2 (GRK2) and promotes neutrophil accumulation at infection sites and quick elimination of pathogens [137]. The gene discussed is CXCR2; the disease is infection.