In HIV-infected patients with hypertriglyceridemia, fenofibrate regulates chemokine gene expression in circulating leukocytes, thereby reducing the expression of C-C motif chemokine receptor 2 (CCR2) and C-X3-C motif chemokine ligand 1 (CX3CL1) to mitigate inflammatory responses [112]. The gene discussed is CX3CL1; the disease is hypertriglyceridemia.