Fenofibrate activates PPAR-α and its target genes to prevent NASH in a murine model of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced steatohepatitis-like hepatocellular damage [86] and a mouse model of HFD-fed NASH [87]. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatohepatitis.