CXCL8 and acute respiratory distress syndrome: In ALI, a large number of immune cells, such as neutrophils, macrophages, lymphocytes, platelets, etc., are recruited and overactivated in the lungs, increasing the proinflammatory cytokine levels, including interleukin β (IL-β), IL-8, and tumor necrosis factor α (TNF-α), which induce cytokine storm.