The oxidative stress markers in lung tissues, inflammatory factors in serum, cell count and neutrophil levels in BALF, and the Nrf2/HO-1 and JNK/NF-κB signaling pathways-related proteins’ levels were identified by immunofluorescence staining and western blotting to further explore the potential mechanisms of SIV effects in the ALI rats. This evidence concerns the gene HMOX1 and acute respiratory distress syndrome.