CUBN and Stroke: To this end, we studied the association of serum Igs with atherosclerotic CVD (ACVD; composite of myocardial infarction, revascularization, and stroke), cardiovascular (both atherosclerotic and non-atherosclerotic) mortality, and CAC scores in a population-based cohort of middle-aged and older individuals with over 17 years of follow-up.