Furthermore, preventing phosphorylation of Y118-Paxillin inhibits cell migration in vitro compared with the expression of the Y118E-Paxillin phosphomimetic, but preventing phosphorylation of Y118-Paxillin promotes cell migration in vivo in both migrating tumor cells and macrophages, and these differences correlate with the differential cellular interactions of CRKII and DOCK180/RacGEF with Paxillin. The gene discussed is CRK; the disease is neoplasm.