PXN and osteosarcoma: However, contrary to these findings, it has also been shown that Y118-Paxillin phosphorylation correlates with advanced human osteosarcoma metastatic stages, with highly metastatic osteosarcoma cell lines expressing high levels of pY118-Paxillin and lowly metastatic cell lines expressing low levels of pY118-Paxillin (Azuma et al., 2005).