Knowledge of FAK inhibition in regulating cancer cell migration or cancer metastasis is largely based on in vitro cell culture studies where FAK inhibitors alter the dynamics and formation of focal adhesion structures (Stutchbury et al., 2017; Chan et al., 2009) and downstream signals (Sieg et al., 2000; Meng et al., 2009), leading to reduced cell migration. This evidence concerns the gene PTK2 and cancer.