We (Rocha et al., 2017) and others (Sawyer et al., 2015; Capel et al., 2018; Carr et al., 2015; Masingue et al., 2017; Piscosquito et al., 2015) recently identified biallelic R707W mutations in the nuclear MFN2 gene in patients with a remarkable adipose phenotype characterised by extreme upper body adiposity (lipomatosis) and lower body lipodystrophy. The gene discussed is MFN2; the disease is lipodystrophy.