In vitro studies of mature AMPs must be conducted in vivo to enable the clinical advancement of peptides.[8] The in vivo experimental models of AMPs can be divided into four main categories: abdominal infection model represented by peritonitis, skin infection model represented by skin scratches, eye infection model represented by keratitis, and other infection models represented by osteomyelitis and lung infection (Figure1). This evidence concerns the gene ADSL and keratitis.