In addition, the administration of CM‐SH‐Au NPs did not significantly increase the accumulation of NPs in the organs.[56] Previous studies have shown that metal‐based nanoparticles have a nonspecific bacterial mechanism of action (they do not bind to specific receptors in bacterial cells), which not only makes it difficult for bacteria to develop resistance, but also broadens the range of antibacterial activity.[57] However, metal nanoparticle‐based AMPs as novel antimicrobial agents for treating bacterial infections, have not shown excellent therapeutic effects in mouse models. Here, ADSL is linked to bacterial infectious disease.