PLXNB2 and cancer: Notably, previous studies have implicated this axon guidance receptor in the regulation of cancer cell proliferation, invasiveness, and metastatic spreading (Le et al, 2015; Yu et al, 2017; Gurrapu et al, 2018; Huang et al, 2021); however, nothing was known about PLXNB2 mutations in cancer, or in other settings.