In fact, whereas we observed a marked reduction in tumor volume in PlxnB2‐silenced ADX43 mice (Fig 5C), there was no significant difference between silenced and control tumors in ADX901 that carry wild‐type PlxnB2 (Fig 5D), further suggesting that G842C‐mutated (but not wt) PlxnB2 is promoting CUP‐derived ADX growth in vivo. Here, PLXNB2 is linked to neoplasm.