A possible mechanism linking T2DM and obesity with subsequent CV complications is inflammation and lipid accumulation due to overexpression of cytokines (tumour necrosis factor‐α, interleukin (IL)‐1, IL‐6, leptin, resist in monocyte chemoattractant protein (MCP)‐1, plasminogen activator inhibitor (PAI)‐1, fibrinogen and angiotensin) by adipose tissue, which have a deleterious effect on blood vessels and can lead to the development of MI and cardiomyopathy.19 This evidence concerns the gene SERPINE1 and obesity due to melanocortin 4 receptor deficiency.