A possible mechanism linking T2DM and obesity with subsequent CV complications is inflammation and lipid accumulation due to overexpression of cytokines (tumour necrosis factor‐α, interleukin (IL)‐1, IL‐6, leptin, resist in monocyte chemoattractant protein (MCP)‐1, plasminogen activator inhibitor (PAI)‐1, fibrinogen and angiotensin) by adipose tissue, which have a deleterious effect on blood vessels and can lead to the development of MI and cardiomyopathy.19 The gene discussed is SERPINB2; the disease is obesity due to melanocortin 4 receptor deficiency.