Additionally, given the role of mop in regulation of Toll and immune deficiency (IMD) pathways as well as IKKβ phosphorylation of Relish (Silverman et al., 2000), the Drosophila NF-κB transcription factor in IMD pathway, it is plausible that alteration in the level of mop is due to effect of reduced IKKβ on innate immune pathways. The gene discussed is NFKB1; the disease is Immunodeficiency.