Tello et al. reported that NDUFA4L2 is a HIF-1α target gene and that NDUFA4L2 inhibits mitochondrial complex I in HeLa cells and MEFs.11 NDUFA4L2 was also overexpressed in hepatocellular carcinoma31 and in glioblastoma, where elevated NDUFA4L2 levels also correlated with reduced patient survival.32 The gene discussed is HIF1A; the disease is glioblastoma.