This is in line with well-established frameworks suggesting a better sensitivity of FDG-PET to AD-related changes compared to MRI (Sperling et al. 2011; Jack et al. 2013) and our recent work showing that FDG-PET is superior to MRI as an input feature for deep learning algorithms for synthesizing tau-PET images (Lee et al. 2022). This evidence concerns the gene MAPT and Alzheimer disease.