In addition to a younger age of onset, this variant of Alzheimer’s disease generally harbors higher levels of neocortical tau pathology, has a shorter disease duration, and lacks the predominant amnestic profile compared to the canonical, amnestic variant of Alzheimer’s disease (Barnes et al. 2018; Ferreira et al. 2020; Smirnov et al. 2021a, 2021b). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.