INS and type 1 diabetes mellitus: Insulin-like growth factor 1 (IGF-1) as an inducer of angiogenesis factor is a peptide hormone that increases cell responsiveness to insulin.17 Numerous literatures have confirmed that in type 1 diabetes, IGF-1 insufficiency is prevalent and therefore sensitivity of cells to insulin decline in the diabetes condition.18 Furthermore, it is shown that IGF-1 therapy refines insulin sensitivity in adults with type 1 diabetes.19 Therefore, IGF-1 can be a useful healing goal in the treatment of heart failure in diabetes condition.