Malanga et al reported that Akt1 hyperactivity due to E17K point mutation might cause significant progression in these cancers.28 Smoking is the leading cause of lung cancer and 85-90% of patients use tobacco.29 Tobacco carcinogen prompts PI3K-dependent activation of Akt in the lung epithelial cells.30 Moreover, tobacco constituents can activate the PI3K/Akt pathway by activating various upstream signals of PI3K, containing Ras, growth factor tyrosine kinase receptor, and phosphatase tensin homolog deleted on chromosome ten (PTEN). The gene discussed is AKT1; the disease is cancer.