Malanga et al reported that Akt1 hyperactivity due to E17K point mutation might cause significant progression in these cancers.28 Smoking is the leading cause of lung cancer and 85-90% of patients use tobacco.29 Tobacco carcinogen prompts PI3K-dependent activation of Akt in the lung epithelial cells.30 Moreover, tobacco constituents can activate the PI3K/Akt pathway by activating various upstream signals of PI3K, containing Ras, growth factor tyrosine kinase receptor, and phosphatase tensin homolog deleted on chromosome ten (PTEN). This evidence concerns the gene PTEN and lung carcinoma.