Matrix metalloproteinases (MMPs) show a specific function in cancer metastasis.53 Several types of MMPs, such as MMP-2, MMP-7, and MMP-9, increase in patients with lung cancer.54,55 In some studies, it is observed that Akt signaling activation has the main link to MMPs expression and its regulation.55 Accordingly, the Akt/mTOR pathway targeting lung cancer cells can have useful effects on growth control and proliferation. Here, MMP2 is linked to lung cancer.