Akt phosphorylation was detected in human bronchial epithelial cells before malignancy24; activated Akt was also discovered in pre-neoplastic bronchial lesions and an increase in the incidence and progression of lung cancer.25 Phosphorylation and hyperactivation of Akt were detected in 30-75% of NSCLCs.26 Furthermore, phospho-Akt (p-Akt) was shown in 70% of SCLCs patients by immune-histochemical analysis,27 which proved the role of Akt hyperactivation in lung cancer progression. This evidence concerns the gene AKT1 and lung cancer.