Overexpression of cyclin D1 has been shown in some studies and it has a close correlation with NSCLCs tumorigenesis from the early stage, hence, it can be a molecular biomarker in cancer.44 Activation of the Akt signaling pathway has been shown to increase cell survival through inhibiting some pro-apoptotic proteins, such as BAD, and increasing various anti-apoptotic factors such as survival.45 On the other hand, Akt can inhibit apoptosis by influencing FOXO protein. The gene discussed is AKT1; the disease is cancer.