HIF1A and cancer: Hypoxia is an important factor for solid tumors enhancing the hypoxia-inducible factor-1 (HIF-1).48-50 HIF-1 can increase vascular endothelial growth factor (VEGF) expression that is an essential component of endothelial vascular permeability and cell proliferation.51 One of the leading causes of cancer mortality is metastasis that occurs at different rates in various cancers.52 Numerous factors are involved in the development and metastasis.